Success on 3rd IVF round after 5 abnormal embryos

UWOF #14: Success on 3rd IVF round after 5 abnormal embryos

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After two failed IVF cycles and five aneuploid/mosaic embryos, a 36-year-old patient with unexplained infertility became pregnant from a PGT-A normal 5AA embryo following a protocol change that included Lupron flare, HGH, and PICSI.

💬 These stories are part of the Uterine Wall of Fame — a growing collection of real IVF success stories submitted by patients who faced challenging scenarios like poor-quality embryos or low AMH. The UWOF is a project by Remembryo / Embryoman, a site that highlights new IVF research. All UWOF posts are free to access (no subscription required).

⚠️ These stories are personal experiences, not medical advice or scientific evidence. Success stories are more likely to be shared than unsuccessful ones, so they should not be interpreted as proof that a treatment works. Always discuss treatment decisions with your doctor.

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📊 Story Snapshot 👩 Age: 36
📆 Years trying: 2
🧬 Embryo: 5AA, euploid
🧪 Retrievals: 3
🐣 Transfers: 1
💊 Diagnosis: Unexplained infertility, High aneuploidy
📈 Outcome: 16 weeks pregnant

My husband and I tried to get pregnant naturally for two years before we sought help and got all the fertility testing done. At 35 and 38 we were diagnosed with unexplained infertility.

We first did three IUIs. All negative. So we decided to move on to IVF.

I had just turned 36 before my first egg retrieval. We got 14 eggs, 8 mature, 6 fertilized. We sent 3 embryos for PGS testing which resulted in 2 abnormal and 1 mosaic. I was devastated.

We took a month off and then jumped in again for round 2. This time we got 18 eggs, 14 mature and 10 fertilized. Everything looked great on day 3 and by day 6 we only had 2 embryos to send for testing. Again, both abnormal.

My doctor encouraged us to try one more time. We switched from antagonist to lupron flare protocol, added HGH and did PICSI instead of ICSI. We got 18 eggs, 13 mature, 11 fertilized and sent 6 for PGS testing which resulted in 2 normal, 3 abnormal and 1 unknown. 

We did a hysteroscopy to remove some polyps that had developed from the retrieval rounds and then transferred our beautiful 5AA PGS normal embryo. I’m now 16 weeks pregnant! 

We almost gave up. Other doctors I consulted with suggested donor eggs. I’m so glad our doctor encouraged us to try again. 

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Want to learn more about aneuploidy? Check out my guide on what causes aneuploidy.

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