A 2025 study found that after a first frozen embryo transfer, experiencing an early pregnancy loss did not increase the risk of loss in the next transfer, for both euploid or untested embryos.
Embryoman
In a 2025 study, researchers masked mosaic PGT-A results and found that mosaic reporting did not meaningfully improve embryo selection or live birth prediction beyond standard criteria, suggesting that PGT-A’s main clinical value lies in identifying clearly aneuploid embryos.
A 2026 study suggests that restoring the protein SGO1 can reduce early chromosome separation in eggs, a process that might help reduce embryo aneuploidy, though this was not directly tested.
In DOR patients, a 2025 study found that follicles measuring 15–17 mm at the time of egg retrieval were associated with the best outcomes, suggesting that optimal trigger timing in this group might occur earlier than standard thresholds used for normal responders.
Here’s your IVF research roundup for December 2025. Each month, I highlight everything I’ve shared on Remembryo — including new IVF study summaries, popular social posts, answers to community questions, and a full list of research highlights with links and short summaries from my newsletter. The paywall is off for this post.
A 2025 study suggests that most patients with recurrent pregnancy loss who transfer up to 3 euploid embryos go on to have a live birth, though data from later transfers are limited.
These are the top 5 posts that got the most engagement on social media or the most page views here on Remembryo in 2025. No paywall on this post.
In a 2025 meta-analysis, day 5 blastocysts were linked to higher pregnancy and live birth rates than day 6 blastocysts, while newborn outcomes were similar and poor quality day 5 embryos showed comparable potential to good quality day 6 embryos.
After a failed retrieval and two poorly grade embryos (3BC+ and 2CB-), this patient had back-to-back success: her first transfer at 38 led to a son, and the second at 40 is now a 12-week pregnancy.
A 2025 review found that men with infertility are more likely to have certain health conditions, but the reasons aren’t clear and the overall risks are still low, suggesting that fertility testing can be a good chance to check on general health.
This post provides a short summary of select news releases/studies from the American Society for Reproductive Medicine (ASRM) 2025 meeting in Texas. These studies may not have been published or peer reviewed yet.
A 2025 study introduces the term “oocyte and early embryo competence defects” to describe younger IVF patients who repeatedly have no transferable embryos due to low quality eggs, finding that about 13–23% had genetic changes.
Here’s your IVF research roundup for November 2025. Each month, I highlight everything I’ve shared on Remembryo — including new IVF study summaries, popular social posts, answers to community questions, and a full list of research highlights with links and short summaries from my newsletter. The paywall is off for this post.
A 2025 study showed that supplement use is widespread among IVF patients, with mixed impressions, limited evidence, and frequent confusion that leads many people to seek guidance from online communities rather than from clinical recommendations.
In a 2025 study, researchers found that poor mitochondrial activity limits the ability of immature eggs to reach maturity, leading to reduced maturation in eggs from older women.
A small 2025 study found that most pregnancies show detectable hCG by day 6 after a blastocyst transfer, and those that first become positive on day 8–10 have higher rates of biochemical and ectopic pregnancy and a lower chance of ongoing pregnancy.
A 2025 case report shows that some ICSI-derived 3PN embryos can be rescued by removing the extra female pronucleus, resulting in a healthy live birth, but the technique remains experimental.
A 2025 study found that aging eggs and their support cells may have increased ribosome activity that contributes to reduced egg quality, and early clinical results suggest that rapamycin may help improve embryo quality and pregnancy rates.
A 2025 study found that 0PN zygotes can actually be normally fertilized but missed during the standard 16–18 hour fertilization check, while those that never form pronuclei are likely unfertilized eggs, supporting a slightly earlier check around 16–17 hours and continued culture of 0PNs to the blastocyst stage for confirmation of fertilization.
A 2025 meta-analysis combined the results of 22 studies and found no clear improvement in live birth rates from hormonal add-on for poor ovarian response, though growth hormone and testosterone ranked as the most promising options, and growth hormone increased the number of eggs retrieved.
Here’s your IVF research roundup for October 2025. Each month, I highlight everything I’ve shared on Remembryo — including new IVF study summaries, popular social posts, answers to community questions, and a full list of research highlights with links and short summaries from my newsletter. The paywall is off for this post.
A 2025 study of single-blastocyst transfers found no increase in birth defects or adverse pregnancy outcomes when transferring poor quality embryos compared to good quality ones.
After three failed transfers of euploid embryos, this patient discovered she had hydrosalpinx. After surgery to remove her damaged tube, she spontaneously conceived identical twins — and is now 14 weeks pregnant.
Using a new non-toxic imaging method, researchers watched living human embryos divide in real time and discovered that chromosome separation errors linked to mosaicism can arise even at the blastocyst stage, showing that mosaicism is a dynamic process rather than one confined to early development.
A 2025 review found that sperm DNA fragmentation testing provides useful insight into male infertility and may help in select cases, but inconsistent evidence, lack of test standardization, and variable results limit its routine use in fertility care.
A 2025 study showed that male obesity was linked to slightly slower embryo development, poorer ICM quality, and a higher miscarriage risk in donor egg IVF cycles, suggesting that paternal weight can subtly influence embryo health and pregnancy outcomes.
A 2025 randomized trial found that men who took the combined antioxidant supplement Impryl for six months had no improvement in semen quality or pregnancy rates, and in some cases slightly worse outcomes, suggesting that routine antioxidant use may do more harm than good for some male infertility patients.
A 2025 study of women with repeated IVF failure and unexplained infertility found that about 13% had mutations affecting egg or embryo development, mostly in the TUBB8 and PATL2 genes, suggesting that many “unexplained” cases may have underlying genetic causes.
Researchers in a 2025 study showed that women with endometriosis or adenomyosis had lower IVF success overall after 3 IVF cycles, with more differences in the first, fresh transfer.
Researchers in a 2024 study showed that by artificially removing the embryo’s zona (shell) right after fertilization reduced fragmentation, improved blastocyst development, and led to live births in patients with repeated IVF failure, though the findings are still preliminary and need confirmation in larger trials.