Researchers in a 2022 study performed a meta-analysis to combine the results of 8 ERA studies and found no differences in live birth, pregnancy and miscarriage rates among women who performed the ERA or didn’t.
Implantation
Researchers in a 2022 study performed a meta-analysis to combine the results of studies examining the transfer of a good and poor quality embryo together (vs one good quality embryo alone), and found no differences in pregnancy or live birth rates, but increases in the rate of multiples.
Researchers in a 2022 study compared the impact of endometrial thickness on pregnancy outcomes in fresh and frozen embryo transfer cycles.
This post covers the variety of reasons embryos can fail to implant or miscarry, including as a result of advanced maternal age, chromosomal translocations, lifestyle, endometritis, the microbiota, immunological issues, endometrial receptivity, the clinic, and more. Note that this is not a complete list, and will be updated periodically.
Researchers in a 2020 study found that sperm from males in couples with recurrent pregnancy loss were more likely to be aneuploid, potentially leading to the diagnosis.
NK or natural killer cells play an important (and controversial) role in IVF. Most evidence suggests that there is no link to NK cell levels and pregnancy outcomes, and that immunotherapies that target NK cells in IVF show no benefit. Although there may be a certain group of patients that benefit. We’ll also discuss how uterine NK cells can support pregnancy, with information on their KIR receptors and HLA-C on the embryo, and how this can lead to embryo “rejection.” Finally, we’ll look at the overall problems with NK cell testing.
