Artificial oocyte activation (AOA)

Italian fertility group issues 2025 guidance on 28 IVF add-ons
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The Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) has issued new guidelines on 28 IVF add-ons, outlining which may help in certain situations, which lack evidence, and which should be limited to research.

Artificial oocyte activation for IVF improves fertilization, live birth rates in meta-analysis
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A 2024 meta-analysis combined the results of 12 studies comparing the use of artificial oocyte activation (AOA) on IVF outcomes. They found that there were increases in fertilization and live birth rates, but only in patients with a history of fertilization problems.

Evidence-based recommendations from ESHRE for 27 IVF add-ons
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Researchers in a 2023 study review the use of 27 IVF add-ons and provide recommendations by ESHRE, with only several that are recommended or could be considered for the general infertility population.