A 2026 review explored why endometriosis surgery doesn’t always lead to pregnancy, highlighting factors like recurrence, undetected lesions, and underlying biological processes that aren’t addressed by surgery.
Endometriosis
Researchers in a 2025 study showed that women with endometriosis or adenomyosis had lower IVF success overall after 3 IVF cycles, with more differences in the first, fresh transfer.
A 2025 study found that PCX, a surface molecule on endometrial cells, may lead to a shorter implantation window in women with endometriosis and might explain the stickiness of lesions outside the uterus.
A 2024 study combined studies involving unexplained infertility patients and endometriosis, finding that nearly half of them have the condition.
Researchers in a 2024 study found lower cumulative live birth rates in patients with a particular type of endometriosis (DIE and/or ovarian endometrioma) that was diagnosed using transvaginal ultrasound.
Researchers in a 2023 study found that patients with or without endometriosis have comparable live birth rates after transferring a euploid embryo, although patients may have been surgically treated (a limitation). Endometriosis patients are more likely to produce aneuploid embryos.
Laparoscopy is the gold standard for diagnosing endometriosis, but other non-surgical tests are showing potential. Here we’ll take a brief look at ReciptivaDx based on the BCL6 protein, the Endotest and DotEndo test based on a miRNA signature, the EMScore which is based on a gene expression signature, and imaging tests like ultrasound and MRI.
This post reviews what research currently shows about the vaginal and endometrial microbiome and how it may relate to fertility and IVF outcomes. While Lactobacillus species are often considered beneficial and are commonly found in the reproductive tract, studies examining whether microbiome differences actually affect IVF success have produced mixed results.
Researchers in a 2023 study combined the results of 74 studies to investigate what factors contribute to euploid live birth and miscarriage rates, identifying embryo quality, maternal age, specific diagnoses, repeat freeze/thaw, and other factors.
Researchers in a 2022 study performed a systematic review and meta-analysis on women with endometriosis undergoing IVF and found no change in live birth rates, but an increased risk of obstetric and perinatal outcomes, however patients were diagnosed without laparoscopy and didn’t account for treated patients.
Researchers in a 2022 study found that the combination of endometriosis and adenomyosis results in lower cumulative live birth rates after IVF, particularly in those with T2 high-signal intensity myometrial spots as evaluated by MRI.
