Researchers in a 2026 guideline review provide evidence-based recommendations from ESHRE on ovarian stimulation for IVF/ICSI, covering protocols, medications, monitoring, and safety.
Follicle development
In DOR patients, a 2025 study found that follicles measuring 15–17 mm at the time of egg retrieval were associated with the best outcomes, suggesting that optimal trigger timing in this group might occur earlier than standard thresholds used for normal responders.
A 2025 study found that aging eggs and their support cells may have increased ribosome activity that contributes to reduced egg quality, and early clinical results suggest that rapamycin may help improve embryo quality and pregnancy rates.
A new study found that selecting FSH type based on a woman’s FSH receptor (FSHR) genotype may improve IVF pregnancy and live birth rates, particularly when using rFSH for NN genotypes and uFSH for NS or SS genotypes.
What’s the ideal follicle size for IVF? Researchers in a 2022 study compared follicle size at the time of trigger and related it to rates for egg maturity, fertilization, good quality embryos and euploidy. They also examined the association between follicle size and age and BMI.
Researchers in a 2020 study compared IVF outcomes by follicle sizes, and found that larger follicles generally produced mature eggs that were more likely to develop into blastocysts.
This post discusses the use of supplements to improve egg quality for IVF success, exploring the supporting evidence for a range of supplements like N-acetyl-cysteine, Melatonin, L-arginine, Myo-inositol, CoQ10, L-carnitine, DHEA, folic acid/folate, and vitamins E, C, D, and B.