In a 2025 study, the sperm selection device Zymot modestly improved blastocyst development compared with conventional sperm processing method (density gradient centrifugation) in donor egg cycles using frozen sperm, though fertilization rates were similar.
Researchers in a 2023 study evaluated 34 common male fertility sperm supplement brands for safety and efficacy. They found that the majority exceeded the recommended daily allowance, with two that exceeded the tolerable upper intake level. Less than half had supporting studies for their use, with the overall quality of evidence being ranked as poor.
Researchers in a 2022 study performed a systematic review and meta-analysis on infertile men who used antioxidant supplements, and found a benefit in pregnancy and semen parameter outcomes.
Researchers in a 2022 study examined the influence of paternal factors, such as semen parameters, paternal BMI and age, on aneuploidy.
Researchers in a 2020 study report on the results of the MOXI trial that tested the effectiveness of a sperm supplement cocktail (containing vitamin C, vitamin D, vitamin E, selenium, and more) and found no benefit.
Researchers in a 2020 study found that sperm from males in couples with recurrent pregnancy loss were more likely to be aneuploid, potentially leading to the diagnosis.
