A day 6 mosaic embryo led to pregnancy at 41 for a patient who had undergone trachelectomy, faced cancer, and endured 13 IUIs and multiple losses.
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๐ Story Snapshot
๐ฉ Age: 41๐ Years trying: 6 years
๐งฌ Embryo: Day 6 4AB mosaic (segmental deletion 6q23)
๐งช Retrievals: 3 (+13 IUIs)
๐ฃ Transfers: 3
๐ Diagnosis: Uterine issues, Recurrent pregnancy loss
๐ Outcome: Pregnant at 41 weeks
Iโm ready for a baby but Iโm diagnosed with cervical cancer at age 34 โadenocarcinomaโ. I have a trachelectomy, the removal of the entire cervix and a portion of the upper vagina, and a cerclage is placed at the same time. We โre trying to conceive but the stenosis and scar tissue prevent it from happening!
First IUI is ridiculously painful, as no catheter can go through this tiny hole (pseudo cervix). After trying many dilations, cytotec, surgeriesโฆI have a second and third IUI. Still BFN. Transfers are way too painful โ I passed out on my third IUI.
With IUI number 4, Iโm pregnant! Finally! Unfortunately our daughter is stillborn after PPROM and sepsis. I delivered her via classical C section (vertical) and need to wait at least a year before trying again.
I am 38 completely devastated and heartbroken. I found out later that my cerclage failed (remember I have no cervix).
I had the cerclage removed and placed a TAC (transabdominal cerclage). We try to conceive again.
A total of 13 IUIsโฆ
Many pregnancies that result in early losses!
Iโm emotionally and financially drained. I had heard about a miracle IVF clinic and I am ready to move forward. I remember my first phone consultation with the doctor, at 6 am on a parking lot in my car (I had to be alone that day). Iโm concerned about my stenosis and I keep asking him ifย he had patients with trachelectomy before!
His answer was โweโll get through this cervixโ.
I order some meds and Iโm ready to start a new journey.
My amazing OBGYN supports me and allows me to perform all my IVF scans at her office with a great tech. I am ready for my first retrieval.
Iโm already 39, and didnโt respond well to conventional IVF. But after a first canceled IVF I decide toย try mini IVF with femara 12.5mg a day, gonal-f 75 every other day and cetrotide. Iโm ready to retrieveย whatever I have! I got 2 eggs.
One embryo and a short BFP. But itโs reassuring that the doctor was able to do the transfer.ย
A second IVF will fail. Iโm almost 40 and I decide to try another mini IVF. I have 4 eggs 4 embryos on day 3. They are all fair or poor! Iโm so sad that I almost forget about them and decide to transfer an embryo from a donor. Here again BFN!
I emailed the embryologist and ask him to thaw my embryos and grow them to blast in order to do PGT-A! At this point, I am not expecting anything. Few days later I find out that one embryo made it to blast on day 6 and was biopsied! When the report comes back, it says โaneuploidโ
Iโm ready to discard it.
But I want to know the gender before I do it. I call the embryologist, he tells me โitโs a maleโ. Iโm sitting outside under a coconut tree and when I hear itโs a male I shut my eyes and see my baby boy running everywhere.
This flash lasted less than a second. But I clearly saw it, โhimโ. I asked if the embryo was truly aneuploid or mosaic? He tells me โmosaic Del 6q23โณ. I donโt remember anything from there.
I made some phone calls the following days, weeksโฆTalked to a genetic counselor who told me NOT to transfer it. And as I learned about mosaicism, I decide to take the risk to transfer it along with a donor egg embryo!
The day has come. Iโm ready for the transfer. When I come to the clinic, the embryos from the donors didnโt grow to blast. My mosaic embryo thawed pretty well but I am completely devastated!
The transfer is too painful the doctor decided to do it under anesthesia. When I wake up, Iโm still a little dizzy, and I hear, โIโm sorry, we couldnโt pass a catheter through, too much scar tissueโ.
I leave to go back home, crying and broken. Myย mosaic embryo is back on ice again. The embryos from the donors died the next morning. The doctor is willing to help me no matter what!
We make a plan for next time. Try a transmyometrial transfer. Itโs a transfer through the vaginal wall. So this time Iโm doing a natural FET and Iโm ready to transfer after a positive OPK.
Iโm here again and I take another selfie few second before the transfer, this time, we are transferring one embryo. My mosaic deletion 6q23 male. A day 6 blast 4AB.ย
The transmyometrial was done within seconds. 3 days later, I see a faint line on a HPT. First beta is great. First ultrasound is overwhelming, Iโm really pregnant!
I am almost 41 and Iโm the happiest mom on earth.

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