Thrombophilia is a group of inherited genetic disorders that affect blood clotting (thrombosis) in the blood vessels. Since successful implantation requires an adequate blood supply to the embryo/fetus, those with thrombophilia might have a reduced ability for successful implantation.
Two genes are often attributed to thrombophilia in implantation failure: factor V (which is a protein involved in blood clotting), and MTHFR.
Synonyms:
MTHFR, factor V