Single nucleotide polymorphism. We all share about 99.9% of the same DNA sequence, what makes us different from each other are SNPs (pronounced “snips”) which occur about 1 in every 1000th base pair in our DNA sequence. SNPs can be useful markers for DNA analyses like PGT-A.
SNP karyotyping, often performed using SNP microarrays, is a PGT-A technique that analyzes hundreds of thousands of SNPs across the genome to create a detailed genetic map of an embryo from its biopsy. This method helps to reveal the parental origin of each chromosome, which can’t be identified through conventional PGT-A using NGS.
Synonyms:
single nucleotide polymorphism, SNP karyotype, SNP karyotyping, SNO microarray, SNP array