After 6 miscarriages, a woman conceived naturally following sitagliptin (an anti-diabetic medication) and later had a second healthy baby from a Day 6 5AB high-level segmental mosaic embryo.
⚠️ These stories are personal experiences, not medical advice or scientific evidence. Success stories are more likely to be shared than unsuccessful ones, so they should not be interpreted as proof that a treatment works. Always discuss treatment decisions with your doctor.
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📊 Story Snapshot
👩 Age: 32📆 Years trying: 6 years
🧬 Embryo: Day 6 5AB high-level segmental mosaic
🧪 Retrievals: 1
🐣 Transfers: 3
💊 Diagnosis: Unexplained infertility, Recurrent pregnancy loss
📈 Outcome: Two live births (1 natural, 1 FET)
We started trying for a family when we were both 27, but after 18 months of infertility we went for tests which didn’t reveal anything wrong.
We were given clomid and I fell pregnant the first month but had a missed miscarriage at 10 weeks. We then fell pregnant 3 more times but miscarried. We had lots more testing and tried various protocols with our 3rd and 4th attempts (steroids, intralips, blood thinners, progesterone) but nothing helped.
My doctor suggested we do IVF with PGT-A testing and we had a fantastic result with 14 blastocysts. Of the 14, only 2 were euploid and 6 mosaic (1 was a low level +21 that we wouldn’t transfer, and two were high complex mosaics). We again had missed miscarriages with the two euploids (so 6 miscarriages on total).
I spoke to a fertility clinic in Greece who suggested I take the anti-diabetic medication sitagliptin (similar to metformin) for 3 months prior to IVF transfer 2 (pregnancy 6) and after miscarrying, I resumed. I then fell pregnant naturally without a period after 6th miscarriage and carried her full term.
We were told at 10 weeks pregnant we would likely lose her as there was skin edema, at 15 weeks she was diagnosed with Talipes, and at 20 weeks she was diagnosed with a heart condition (BSVC and coarctation of the aorta). She also had short femurs and I developed polyhydramnios (too much amniotic fluid surrounding the fetus) — all red flags for a chromosomal disorder.
But she was born healthy at 37 weeks and apart from treating the Talipes, she has no health concerns and is the smartest 3 year old!
We decided to go back to our embryos and, from my research I pushed to transfer the high level segmental mosaic (missing a large section of chromosome 1) before the two low level ones. I took sitagliptin again for 3 months before, and did an unmedicated FET. My son was born healthy!
What would you say to someone who’s going through what you went through?
Never give up and do your own research and advocate for yourself – no one knows more or cares more about your future than you. It took us 10 years and 6 miscarriages but we have two healthy children
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Want to learn more about mosaic embryos? Check out my guide here.
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