Aneuploid embryo success rates after transfer are very low, with about 1–2% leading to a live birth, likely due to undetected mosaicism after PGT-A rather than true whole chromosome aneuploidy.
Aneuploid embryo success rates
A new case report describes the healthy birth of dizygotic twin girls from embryos labeled as aneuploid by PGT-A, highlighting the limitations of embryo testing and the need to reconsider strict discard protocols.
A 2025 study shows that segmental abnormalities detected by PGT-A in the trophectoderm don’t always match the ICM, suggesting that these embryos may still be viable for transfer.
Researchers, in a 2024 study, have discovered that mutations in genes that code for specialized proteins called kinesins could lead to increased risk of aneuploidy and accelerate the aging process.
Researchers in 2024 report on live births after segmental aneuploid transfers, finding that they have similar rates as high level mosaic segmental aneuploids.
Aneuploid embryos, with an abnormal number of chromosomes, are a major cause of miscarriages, often linked to maternal age and errors in meiosis. In this post, we’ll explore what chromosomes and aneuploidy are, how meiosis errors cause aneuploidy, and the factors contributing to these errors, including age, genetics and mitochondrial dysfunction.
Researchers in a 2022 study reported on the outcomes of 144 “abnormal” embryos, consisting of aneuploids and mosaics, finding a single live birth with an aneuploid and more favorable results with mosaics.
Researchers in a 2020 study performed a clinical trial and transferred aneuploid embryos, finding that no whole chromosome aneuploids led to a live birth, while segmental aneuploids did.