Researchers in a 2026 randomized trial found that ~9 weeks of transdermal testosterone before IVF didn’t improve pregnancy rates or egg numbers in women with diminished ovarian reserve.
Advanced maternal age
A 2026 study suggests that restoring the protein SGO1 can reduce early chromosome separation in eggs, a process that might help reduce embryo aneuploidy, though this was not directly tested.
In DOR patients, a 2025 study found that follicles measuring 15–17 mm at the time of egg retrieval were associated with the best outcomes, suggesting that optimal trigger timing in this group might occur earlier than standard thresholds used for normal responders.
In a 2025 study, researchers found that poor mitochondrial activity limits the ability of immature eggs to reach maturity, leading to reduced maturation in eggs from older women.
A 2025 study found that aging eggs and their support cells may have increased ribosome activity that contributes to reduced egg quality, and early clinical results suggest that rapamycin may help improve embryo quality and pregnancy rates.
A 2025 meta-analysis combined the results of 22 studies and found no clear improvement in live birth rates from hormonal add-on for poor ovarian response, though growth hormone and testosterone ranked as the most promising options, and growth hormone increased the number of eggs retrieved.
A 2025 study introduces the FORTUNE model, developed from over 10,000 PGT-A cycles, that uses age, ovarian reserve, partner age, and BMI to predict how many euploid embryos a patient is likely to produce by grouping patients into five prognosis categories.
A 2025 meta-analysis combined 151 studies on interventions for advanced maternal age (>35) patients. It found no clear advantage to any specific stimulation protocol or FSH type, no benefit from routine ICSI, and decreased live birth with assisted hatching, while more research is needed on blastocyst versus cleavage-stage transfer and on PGT-A with modern methods.
A large 2025 study charts how AMH levels decline with age in over 22,000 women, revealing when diminished ovarian reserve (DOR) becomes more common, regardless of infertility status.
A 2025 case report describes a live birth in a 46-year-old woman using her own eggs through IVF, adding to a small number of published cases showing that pregnancy at this age, while uncommon, is still possible without add-ons or PGT-A.
In a 2025 study, researchers estimated how many frozen eggs are needed, by age, to reliably yield three euploid blastocysts or achieve one, two or three live births, offering practical guidance for egg freezing patients.
A 2025 study compared cumulative live birth rates for patients transferring up to 15 untested embryos. Besides the CLBR based on single blastocyst transfers and age, they found differences based on ovarian response and blastocyst formation rates. They also suggested a new way to define recurrent implantation failure.
A 2025 study found that RIF and RPL patients with abnormal EMMA & ALICE results that had antibiotic and/or probiotic treatment showed similar pregnancy rates to those with normal EMMA & ALICE results.
A 2025 opinion article highlights some of the issues with PGT-A, mainly its uncertain benefit, technical flaws, high costs, and the risk of discarding potentially viable embryos.
Researchers, in a 2024 study, have discovered that mutations in genes that code for specialized proteins called kinesins could lead to increased risk of aneuploidy and accelerate the aging process.
A 2024 study compared cumulative live birth rates for patients aged 40 to 48, finding that increasing age led to decreasing chances of birth.
A 2024 study explored the male and female factors that are associated with embryo euploid rates, finding that male characteristics had a minor influence.
A 2024 case report details a patient who had success transferring a 4 cell embryo on day 4 — an embryo that some clinics wouldn’t have considered for transfer.
A 2024 meta-analysis combined the results of 38 studies investigating treatments for diminished ovarian reserve patients. DHEA, testosterone, high-dose gonadotropins and delayed start protocols all improved the number of eggs retrieved.
A 2024 study compared IVF outcomes and pregnancy rates for patients of different ages (<32 to >40) who had their first single embryo transfer.
Aneuploid embryos, with an abnormal number of chromosomes, are a major cause of miscarriages, often linked to maternal age and errors in meiosis. In this post, we’ll explore what chromosomes and aneuploidy are, how meiosis errors cause aneuploidy, and the factors contributing to these errors, including age, genetics and mitochondrial dysfunction.
A 2024 meta-analysis combined the results of 20 studies, showing that supplements improved IVF outcomes in women with ovarian aging, especially CoQ10.
A 2024 study compared successful and unsuccessful euploid transfers, finding that female age had no impact, while BMI, embryo quality and the type of FET used did.
In a 2024 study, researchers developed a model to help predict the number of mature eggs needed to obtain at least one euploid, based on age.
