A 2025 case report describes a live birth from a frozen immature egg matured through rescue IVM, suggesting that immature eggs in freezing cycles may have reproductive potential and should not be routinely discarded.
in vitro maturation
The Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) has issued new guidelines on 28 IVF add-ons, outlining which may help in certain situations, which lack evidence, and which should be limited to research.
Researchers performed rescue IVM on immature eggs collected from poor prognosis patients, and found that a large number became mature and fertilized, allowing about 1 in 12 patients to have a live birth that they wouldn’t have had otherwise.
Researchers in a 2023 study review the use of 27 IVF add-ons and provide recommendations by ESHRE, with only several that are recommended or could be considered for the general infertility population.
Researchers in a 2023 study found that older women that are triggered earlier produce immature eggs that may be more competent than mature eggs after rescue IVM.
Researchers in a 2023 study used rescue IVM and found that many immature eggs became mature and had comparable fertilization and euploid rates to sibling mature eggs, although there was a decrease in blastocyst formation rates.
Researchers in a 2023 study used a procedure called “rescue in vitro maturation” to culture immature eggs collected after retrieval overnight, and found that a high proportion became mature and had comparable fertilization to sibling mature eggs, with many going on to form euploids.
Researchers in a 2022 study compared outcomes from mature M2 eggs and M1-M2 eggs that underwent “rescue in vitro maturation” and found that M2 eggs had improved fertilization, blastocyst conversion and euploidy rates, with no difference in pregnancy or live birth rates.