The ASRM published their 2026 guidelines on managing recurrent pregnancy loss (RPL), reviewing which tests and treatments are supported by evidence, which may be considered in certain situations, and which are not routinely recommended.
Thrombophilia
A 2026 meta-analysis combined the results of 105 studies to examine the causes of recurrent pregnancy loss (RPL), finding that unexplained RPL and acquired thrombophilia were the most common.
This post covers the variety of reasons embryos can fail to implant or miscarry, including as a result of advanced maternal age, chromosomal translocations, lifestyle, endometritis, the microbiota, immunological issues, endometrial receptivity, the clinic, and more. Note that this is not a complete list, and will be updated periodically.