Researchers in a 2026 study found that a single ultrasound performed at 45 days of IVF gestation may be sufficient to diagnose many miscarriages without the need for a repeat scan.
Pregnancy loss
Researchers in a 2026 randomized controlled trial found that natural FETs using euploid embryos were associated with lower early pregnancy loss rates and higher live birth rates than medicated transfers, although the study was stopped early.
Researchers in a 2026 study found that higher beta-hCG levels measured 9 days after a single euploid embryo transfer were linked to a higher chance of live birth and a lower chance of biochemical pregnancy loss or ectopic pregnancy.
The ASRM published their 2026 guidelines on managing recurrent pregnancy loss (RPL), reviewing which tests and treatments are supported by evidence, which may be considered in certain situations, and which are not routinely recommended.
A 2026 study used a machine learning model to predict whether a miscarriage was euploid or aneuploid using routine medical data, without PGT-A, and showed moderate ability to distinguish between the two while identifying several associated factors.
A 2025 study found that after a first frozen embryo transfer, experiencing an early pregnancy loss did not increase the risk of loss in the next transfer, for both euploid or untested embryos.
Even when embryos are euploid and pass PGT-A, miscarriage can still happen. A new 2025 study suggests that genetic mutations too small to be seen by standard PGT-A may explain some of these losses.
Researchers in a 2025 study found that women with RPL show distinct immune-related gene activity in their endometrium, identifying a possible molecular signature that could help diagnose or personalize treatment for RPL in the future.
Successful embryo implantation and pregnancy depends on careful control of the immune system. In this post, we’ll explore the general workings of the immune system and its role in pregnancy, examining how dysregulation of immune cells like natural killer (NK) cells and macrophages can impact fertility. Additionally, we’ll look into autoimmunity and discuss how immunotherapies may be used to improve IVF outcomes.
A 2024 study investigated the genetics of over 3,200 miscarriages, finding that two-thirds were associated with a chromosomal abnormality, with trisomy 16 and the 8p23.1 deletion as the most common abnormalities.
Researchers in a 2024 study measured leukocyte (white blood cell) levels in women preparing for pregnancy, and found that miscarriage risk was lower with high total leukocytes. Specific immune cells examined include monocytes, eosinophils, basophils, lymphocytes and neutrophils.
