A 2026 study used a machine learning model to predict whether a miscarriage was euploid or aneuploid using routine medical data, without PGT-A, and showed moderate ability to distinguish between the two while identifying several associated factors.
Pregnancy loss
A 2025 study found that after a first frozen embryo transfer, experiencing an early pregnancy loss did not increase the risk of loss in the next transfer, for both euploid or untested embryos.
Even when embryos are euploid and pass PGT-A, miscarriage can still happen. A new 2025 study suggests that genetic mutations too small to be seen by standard PGT-A may explain some of these losses.
Researchers in a 2025 study found that women with RPL show distinct immune-related gene activity in their endometrium, identifying a possible molecular signature that could help diagnose or personalize treatment for RPL in the future.
A 2024 study investigated the genetics of over 3,200 miscarriages, finding that two-thirds were associated with a chromosomal abnormality, with trisomy 16 and the 8p23.1 deletion as the most common abnormalities.
