Here’s your IVF research roundup for July 2025. Each month, I highlight everything I’ve shared on Remembryo — including new IVF study summaries, popular social posts, answers to community questions, and a full list of research highlights with links and short summaries from my newsletter. The paywall is off for this post.
📬 Like this roundup?
Get IVF research summaries, news highlights, and weekly subscriber-only content straight to your inbox.
Subscribe to the Remembryo Newsletter →
🔗 Original studies are referenced in this post or within the linked Remembryo posts.
💡 Reminder: Terms underlined with a dotted black line are linked to glossary entries. Clicking these does not count toward your paywall limit.
Remembryo posts
Here’s what I covered this month on Remembryo. Click any image to read more.
A 2024 meta-analysis combined the results of 10 studies to show that embryos that are thawed for PGT-A, or rebiopsied after inconclusive results, have lower chances of pregnancy and live birth, with higher miscarriage rates. Read more.
A large 2025 study charts how AMH levels decline with age in over 22,000 women, revealing when diminished ovarian reserve (DOR) becomes more common, regardless of infertility status. Read more.
This post traces the evolution of PGT-A testing in IVF, from early FISH and microarray methods to modern NGS and emerging technologies like nanopore sequencing, highlighting how each advancement improved accuracy, speed, and embryo assessment. Read more.
A 2025 case report describes a live birth in a 46-year-old woman using her own eggs through IVF, adding to a small number of published cases showing that pregnancy at this age, while uncommon, is still possible without add-ons or PGT-A. Read more.
A 2025 randomized controlled trial found that natural cycle FETs led to higher live birth rates and fewer miscarriages than medicated FETs in ovulatory women with a good prognosis. Read more.
A new case report describes the healthy birth of dizygotic twin girls from embryos labeled as aneuploid by PGT-A, highlighting the limitations of embryo testing and the need to reconsider strict discard protocols. Read more.
Even when embryos are euploid and pass PGT-A, miscarriage can still happen. A new 2025 study suggests that genetic mutations too small to be seen by standard PGT-A may explain some of these losses. Read more.
A 2025 study shows that segmental abnormalities detected by PGT-A in the trophectoderm don’t always match the ICM, suggesting that these embryos may still be viable for transfer. Read more.
A new study showed that day 7 embryos may develop more slowly because of stress and disrupted signaling in the inner cell mass, which might help explain their lower success rates. Read more.
Top viewed posts on social
Here you can see the top 3 most popular posts for the month on Instagram, excluding the posts from above.
- AI model trained on 18 million embryo images improves IVF embryo selection. A study introduced FEMI, a foundation model trained on 18 million time-lapse embryo images, which outperformed existing methods in predicting ploidy, assessing blastocyst quality, and tracking developmental timing in IVF. Check out the full study on Nature Communications.
- Lab-grown eggs, sperm could be just years away with in-vitro gametogenesis. Scientists are making rapid progress in lab-grown human eggs and sperm using in‑vitro gametogenesis, which could reach clinics in five to seven years and help treat infertility, though experts warn of significant ethical and safety concerns. Check out the full story on The Guardian.
- Eight healthy births reported from mitochondrial donation in the UK. A UK team at Newcastle Fertility Centre has reported the birth of eight healthy children from mitochondrial donation, a “three-parent IVF” technique that swaps defective mitochondria for healthy donor ones to prevent inherited disease. Check out the full story on Nature.
And here’s the top 3 older Remembryo posts (based on Instagram story views). Click any image to read more.
Researchers in a 2024 study performed an RCT and found that intraovarian PRP resulted in an increased number of eggs retrieved in patients with poor ovarian response, although these eggs weren't more likely to become blastocysts or be euploid after PGT-A and resulted in fewer pregnancies. Read more.
Researchers in a 2022 study compared perinatal outcomes after IVF using donor sperm and found a reduction in preterm births, low birth weights and congenital anomalies compared to babies conceived using partner sperm. Read more.
A 2024 study investigated the genetics of over 3,200 miscarriages, finding that two-thirds were associated with a chromosomal abnormality, with trisomy 16 and the 8p23.1 deletion as the most common abnormalities. Read more.
IVF in the news highlights
Each week in the Remembryo newsletter, I share short summaries of IVF-related stories that made headlines. Below are 5 leading headlines for the month, with the first two summarized:
- Baby born from 30-year-old frozen embryo sets record. A baby boy was born from an embryo that had been frozen for over 30 years, setting a new record for the longest-stored embryo to result in a birth. The embryo, created in 1994 and slow-frozen using older methods, survived thawing and transfer through an embryo adoption program Check out the full story on MIT Technology Review.
- New saliva test may detect endometriosis early. Researchers in France have developed a saliva test that can detect endometriosis with high accuracy, offering a non-invasive alternative to surgery and reducing years of diagnostic delay. This test looks for microRNA markers in saliva and may help identify cases that are hard to see with imaging, especially when symptoms are vague or dismissed. Check out the full story on The Scientist.
- Study finds recurring endometrial defect in miscarriage patients — Check out the full story on The Guardian.
- Preeclampsia risk guidelines may miss the mark — Check out the full story on Stat.
- Doctors say Kennedy’s vaccine policy puts pregnant patients at risk — Check out the full story on The New York Times.
💡 Enjoying this summary?
Join 10,000+ readers who stay updated on IVF research each week:
Sign up here →
IVF questions from the community
Here are select questions that I answered either in my Facebook group or on Reddit.
- Should younger IVF patients with a good prognosis still do PGT-A testing? It might not always be necessary –studies suggest that younger patients with a good prognosis may do just as well or better by transferring the best-looking embryo without PGT-A. False positives are a concern, but embryos flagged as aneuploid do have a higher miscarriage risk. Check this post for the Problems with PGT-A.
- Why do embryos often stop developing after day 3? Is it usually a sperm issue? From what I’ve seen, I believe this is a myth. Around day 3, the embryo’s genome activates, using DNA from both the egg and sperm, so problems from then on can come from either. High rates of embryo arrest may have a genetic component, but arrest can also be caused by mitochondrial issues, oxidative stress, or lab conditions. Read more in my post Embryo Arrest.
- My eggs look granular and have vacuoles. Should I worry? How an egg looks under the microscope is a poor predictor of its true quality. Research linking abnormal morphology to lower success is mixed, and ESHRE/ALPHA guidelines note many eggs with these features can still be used. What really matters is the egg’s inner health including its metabolism, mitochondria, and chromosome machinery, so even “poor looking” eggs can make healthy embryos. Read more in my Complete guide to egg quality.
IVF research brief
🔒 The full research brief for the month begins below (paid subscribers only)
Each week I flag ~20 IVF studies I find most helpful. Some are covered in detail on Remembryo, but paying subscribers get short summaries and links to all of them, organized into categories like implantation, egg quality, PGT-A, etc. Below is the full list of 70 short summaries and links for studies that weren’t featured on Remembryo (available to paying members only).
🔍 Sneak peek: 3 select summaries from the month
- This systematic review of 77 studies found limited and inconsistent evidence to support the routine use of immunological treatments for recurrent implantation failure, highlighting major variability in study definitions and quality. Read more (abstract only)
- This Cochrane review (high quality review) compared ovarian stimulation protocols by combining results from 338 randomized controlled trials involving over 59,000 women. They found that short and long GnRH agonist protocols had similar live birth rates, but rates were lower with protocols that omitted pituitary suppression or used GnRH agonist flare protocols, compared to short GnRH antagonist protocols. Read more (abstract only)
- This narrative review summarizes evidence showing that oxidative stress negatively affects fertility in both sexes and can be reduced through personalized dietary and lifestyle changes, including antioxidant intake, exercise, and avoidance of harmful exposures. Read more (full article)
If you like these, consider subscribing below to get the full list.
If you liked this post and want to support what I do, please consider a paid subscription, Patreon or donate through PayPal!
About Embryoman
Embryoman (Sean Lauber) is a former embryologist and the founder of Remembryo, an IVF research and fertility education website. After working in an IVF lab in the US, he returned to Canada and now focuses on making fertility research more accessible. He holds a Master’s in Immunology and launched Remembryo in 2018 to help patients and professionals make sense of IVF research. Sean shares weekly study updates on Facebook, Instagram, and Reddit regularly. He also answers questions on Reddit or in his private Facebook group.