This couple saved for 4 years to afford IVF and were able to collect only about 100 sperm due to the husband’s childhood cancer. Two untested embryos were transferred at age 40, resulting in healthy boy/girl twins.
Embryoman
A large 2025 study charts how AMH levels decline with age in over 22,000 women, revealing when diminished ovarian reserve (DOR) becomes more common, regardless of infertility status.
This post traces the evolution of PGT-A testing in IVF, from early FISH and microarray methods to modern NGS and emerging technologies like nanopore sequencing, highlighting how each advancement improved accuracy, speed, and embryo assessment.
After being rejected by two clinics due to very low AMH and endometriosis, Jessica gave birth from a 6-cell Day 3 embryo labeled “very poor quality”—and later conceived naturally again.
After 6 miscarriages, a woman conceived naturally following sitagliptin (metformin) and later had a second healthy baby from a Day 6 5AB high-level segmental mosaic embryo.
After 8 IVF cycles, multiple miscarriages, and Hashimoto’s disease, this parent achieved a successful pregnancy at age 42 using untested embryos and aggressive immune treatment — including IVIG, neupogen, steroids and hydroxychloroquine.
A 2025 case report describes a live birth in a 46-year-old woman using her own eggs through IVF, adding to a small number of published cases showing that pregnancy at this age, while uncommon, is still possible without add-ons or PGT-A.
A 2025 randomized controlled trial found that natural cycle FETs led to higher live birth rates and fewer miscarriages than medicated FETs in ovulatory women with a good prognosis.
After a pregnancy loss due to a genetic condition, this parent endured five IVF cycles, genetic screening (PGT-M), and a single transfer of a Day 7 5CC embryo — who is now a healthy 14-month-old daughter.
After two failed IVF cycles and a diagnosis of unexplained infertility, a new doctor recommended laparoscopy—revealing stage II endometriosis and tubal adhesions. Following surgery, this anonymous patient conceived naturally at age 36 and is now 8 weeks pregnant.
This patient went through six IVF cycles with multiple failed transfers and years of unexplained infertility. A final low-stimulation cycle and one day 3 embryo finally led to pregnancy and a baby girl.
A new case report describes the healthy birth of dizygotic twin girls from embryos labeled as aneuploid by PGT-A, highlighting the limitations of embryo testing and the need to reconsider strict discard protocols.
Even when embryos are euploid and pass PGT-A, miscarriage can still happen. A new 2025 study suggests that genetic mutations too small to be seen by standard PGT-A may explain some of these losses.
A 2025 study shows that segmental abnormalities detected by PGT-A in the trophectoderm don’t always match the ICM, suggesting that these embryos may still be viable for transfer.
A low-grade 5CB euploid embryo led to a healthy pregnancy and much-wanted baby, following diminished ovarian reserve, three IVF cycles, and three early losses.
After a failed cycle with an aneuploid embryo and a history of endometriosis and tubal removal, a 4CC euploid embryo led to the birth of a healthy baby girl.
With most embryos arresting and one cycle already failed, a patient transferred three fragmented day 3 embryos—and welcomed a healthy baby girl.
After four retrievals where nearly all embryos arrested before blastocyst, a single 3AB embryo finally led to a healthy 17-week pregnancy at age 42. Cancer and male factor infertility added further complexity to this success.
A grade C blastocyst led to a healthy birth for a 39-year-old patient, even after discouraging IUI and grading outcomes.
Immune therapy and steroid support helped a patient with PCOS conceive after 5 failed transfers—including an ectopic pregnancy. She’s now expecting her baby girl.
Her journey included 10 retrievals, 17 transfers, and 6 heartbreaking losses. The embryo that finally worked? Her worst-graded, untested one.
After two failed IVF cycles and five aneuploid/mosaic embryos, a 36-year-old patient with unexplained infertility became pregnant from a PGT-A normal 5AA embryo following a protocol change that included Lupron flare, HGH, and PICSI.
A double day 3 embryo transfer brought success for a patient with PCOS—after 7 IVF cycles and repeated setbacks, one embryo implanted and became her healthy son.
After multiple losses, failed FETs, and a poor ovarian response, a patient with blocked tubes and immune issues became pregnant after starting Lovenox for antiphospholipid antibodies and transferring a fresh 5BB embryo. She’s now 12.5 weeks pregnant with normal NIPT results.
Eight fibroids were removed in an abdominal myomectomy after a failed transfer. Just five months later, a donor egg embryo led to pregnancy.
After two years of unexplained infertility and a retrieval that produced only day 6 and day 7 embryos, a 30-year-old patient delivered a healthy baby from a day 7, 6AA, PGT-A tested blast, despite early doubts from clinics.
A 28-year-old patient conceived healthy boy–girl twins from a transfer that unknowingly included a day 7 untested embryo—following an initial failed attempt.
After years of struggling with endometriosis and diminished ovarian reserve, a 34-year-old patient conceived from a day 3 transfer using one of just two fertilized eggs. Her daughter was born healthy.
After 4 failed IUIs, a D&C, and polyp removal, this 41-year-old patient with PCOS conceived through IVF using a day 3 untested embryo, and delivered a healthy baby boy just before turning 42.
After seven egg retrieval cycles and multiple failed transfers, a 42-year-old patient decided to skip PGT-A and became pregnant with two untested frozen day 5 embryos.