A 2025 study of single-blastocyst transfers found no increase in birth defects or adverse pregnancy outcomes when transferring poor quality embryos compared to good quality ones.
Embryoman
After three failed transfers of euploid embryos, this patient discovered she had hydrosalpinx. After surgery to remove her damaged tube, she spontaneously conceived identical twins — and is now 14 weeks pregnant.
Using a new non-toxic imaging method, researchers watched living human embryos divide in real time and discovered that chromosome separation errors linked to mosaicism can arise even at the blastocyst stage, showing that mosaicism is a dynamic process rather than one confined to early development.
A 2025 review found that sperm DNA fragmentation testing provides useful insight into male infertility and may help in select cases, but inconsistent evidence, lack of test standardization, and variable results limit its routine use in fertility care.
A 2025 study showed that male obesity was linked to slightly slower embryo development, poorer ICM quality, and a higher miscarriage risk in donor egg IVF cycles, suggesting that paternal weight can subtly influence embryo health and pregnancy outcomes.
A 2025 randomized trial found that men who took the combined antioxidant supplement Impryl for six months had no improvement in semen quality or pregnancy rates, and in some cases slightly worse outcomes, suggesting that routine antioxidant use may do more harm than good for some male infertility patients.
A 2025 study of women with repeated IVF failure and unexplained infertility found that about 13% had mutations affecting egg or embryo development, mostly in the TUBB8 and PATL2 genes, suggesting that many “unexplained” cases may have underlying genetic causes.
Researchers in a 2025 study showed that women with endometriosis or adenomyosis had lower IVF success overall after 3 IVF cycles, with more differences in the first, fresh transfer.
Researchers in a 2024 study showed that by artificially removing the embryo’s zona (shell) right after fertilization reduced fragmentation, improved blastocyst development, and led to live births in patients with repeated IVF failure, though the findings are still preliminary and need confirmation in larger trials.
Here’s your IVF research roundup for August 2025. Each month, I highlight everything I’ve shared on Remembryo — including new IVF study summaries, popular social posts, answers to community questions, and a full list of research highlights with links and short summaries from my newsletter. The paywall is off for this post.
A 2025 case report describes a live birth from a frozen immature egg matured through rescue IVM, suggesting that immature eggs in freezing cycles may have reproductive potential and should not be routinely discarded.
Three euploid embryos failed, and one natural pregnancy ended in miscarriage, but a high level mosaic with a 10% chance from frozen eggs led to a healthy baby boy.
A 2025 study introduces the FORTUNE model, developed from over 10,000 PGT-A cycles, that uses age, ovarian reserve, partner age, and BMI to predict how many euploid embryos a patient is likely to produce by grouping patients into five prognosis categories.
In a 2025 study, the sperm selection device Zymot modestly improved blastocyst development compared with conventional sperm processing method (density gradient centrifugation) in donor egg cycles using frozen sperm, though fertilization rates were similar.
Rosie from Edinburgh conceived after 5 years, 5 failed transfers, and 3 retrievals — thanks to a Day 6 CC embryo. She’s now 20 weeks pregnant with a baby boy.
A 2025 study found that while poor quality blastocysts are less likely to be euploid, some can still lead to healthy live births. Tested poor quality embryos had higher live birth rates and lower miscarriage rates than untested ones, especially when they developed by day 5 instead of day 6.
Diagnosed with premature ovarian failure and endometriosis, this patient went through 10 IVF cycles using her own eggs before finding success with a donor egg embryo. Her son was born in November 2022.
A large 2025 study of donor egg cycles found that poor fertilization in IVF is uncommon, but when it does occur it’s usually caused by sperm rather than the egg. Most cases of low fertilization were sperm-related, while only a minority were linked to eggs or other factors.
A 2025 meta-analysis combined 151 studies on interventions for advanced maternal age (>35) patients. It found no clear advantage to any specific stimulation protocol or FSH type, no benefit from routine ICSI, and decreased live birth with assisted hatching, while more research is needed on blastocyst versus cleavage-stage transfer and on PGT-A with modern methods.
Here’s your IVF research roundup for August 2025. Each month, I highlight everything I’ve shared on Remembryo — including new IVF study summaries, popular social posts, answers to community questions, and a full list of research highlights with links and short summaries from my newsletter. The paywall is off for this post.
A 2025 study suggests that acetaminophen (Tylenol), at levels reached after a standard dose, can disrupt embryo development in experimental models, raising questions about its potential impact on IVF outcomes, although better research in humans is needed before changing clinical practice.
A large 2025 study found that a thin lining (<7 mm) lowered live birth rates in medicated and modified natural FETs, but not in natural cycles, and overall endometrial thickness was not a strong standalone predictor of IVF success.
A 2025 case report describes two IVF patients who conceived triplets from a single embryo transfer and offers insight into just how rare this is.
The Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) has issued new guidelines on 28 IVF add-ons, outlining which may help in certain situations, which lack evidence, and which should be limited to research.
In a 2025 study, researchers tested a noninvasive MRI-like tool that reads an embryo’s metabolic health, accurately predicting which would stop developing and potentially helping select the healthiest for transfer.
This post explains how embryos can split during IVF, especially at the blastocyst stage. It covers the timing of splitting, the different types of identical twins, the factors that make splitting more likely, and how IVF labs can reduce the risk of twins after single embryo transfer.
After four retrievals, three failed transfers, and two miscarriages, Hannah conceived from a fresh 8-cell Day 3 embryo after a laparoscopy for stage 1 endometriosis. She is now 16 weeks pregnant and cautiously hopeful.
Through 7 retrievals, mini IVF, endometriosis surgery, and years of perseverance, Stephanie conceived at 42 from a double transfer of untested Day 6 and Day 7 embryos. She’s now 34 weeks pregnant with a healthy baby girl.
Here’s your IVF research roundup for July 2025. Each month, I highlight everything I’ve shared on Remembryo — including new IVF study summaries, popular social posts, answers to community questions, and a full list of research highlights with links and short summaries from my newsletter. The paywall is off for this post.
A 2024 meta-analysis combined the results of 10 studies to show that embryos that are thawed for PGT-A, or rebiopsied after inconclusive results, have lower chances of pregnancy and live birth, with higher miscarriage rates.