A 2025 study found that nearly one in three IVF patients without PCOS or diabetes had insulin resistance, which was linked to lower success rates, but taking metformin before embryo transfer seemed to help.
Embryoman
A pilot study in 2025 explored whether mitochondrial DNA mutations in follicular fluid could reflect egg quality, finding some early signs of a possible link, but there were some significant limitations.
A 2025 study found that PCX, a surface molecule on endometrial cells, may lead to a shorter implantation window in women with endometriosis and might explain the stickiness of lesions outside the uterus.
A new study found that selecting FSH type based on a woman’s FSH receptor (FSHR) genotype may improve IVF pregnancy and live birth rates, particularly when using rFSH for NN genotypes and uFSH for NS or SS genotypes.
This post summarizes the 2025 ESHRE/ALPHA Istanbul consensus on egg and embryo assessment, offering patients a clear overview of how embryologists evaluate and rank eggs, zygotes, and embryos based on updated international guidelines.
In a 2025 study, researchers estimated how many frozen eggs are needed, by age, to reliably yield three euploid blastocysts or achieve one, two or three live births, offering practical guidance for egg freezing patients.
Researchers in a 2025 study found that women with RPL show distinct immune-related gene activity in their endometrium, identifying a possible molecular signature that could help diagnose or personalize treatment for RPL in the future.
Researchers performed rescue IVM on immature eggs collected from poor prognosis patients, and found that a large number became mature and fertilized, allowing about 1 in 12 patients to have a live birth that they wouldn’t have had otherwise.
A 2025 study compared cumulative live birth rates for patients transferring up to 15 untested embryos. Besides the CLBR based on single blastocyst transfers and age, they found differences based on ovarian response and blastocyst formation rates. They also suggested a new way to define recurrent implantation failure.
A 2025 study compared changes in gene expression in the endometrium of women with or without RIF, finding many differences, with most involving immune cell populations.
While multiple studies have shown the benefit of antioxidant supplements in improving male fertility, what effect excessive supplementation has isn’t clear. This post combines a new study with older studies that show high levels of supplements can harm male fertility. However, these studies all have their limitations, and better quality research is needed to draw conclusions.
