Embryoman
A 2025 study compared cumulative live birth rates for patients transferring up to 15 untested embryos. Besides the CLBR based on single blastocyst transfers and age, they found differences based on ovarian response and blastocyst formation rates. They also suggested a new way to define recurrent implantation failure.
A 2025 study compared changes in gene expression in the endometrium of women with or without RIF, finding many differences, with most involving immune cell populations.
While multiple studies have shown the benefit of antioxidant supplements in improving male fertility, what effect excessive supplementation has isn’t clear. This post combines a new study with older studies that show high levels of supplements can harm male fertility. However, these studies all have their limitations, and better quality research is needed to draw conclusions.
A 2025 study re-analyzed embryos that tested as mosaic by NGS-based PGT-A using SNP karyotyping and found that one-third of those “mosaics” were actually uniformly aneuploid.
A 2025 study found that RIF and RPL patients with abnormal EMMA & ALICE results that had antibiotic and/or probiotic treatment showed similar pregnancy rates to those with normal EMMA & ALICE results.
A 2025 opinion article highlights some of the issues with PGT-A, mainly its uncertain benefit, technical flaws, high costs, and the risk of discarding potentially viable embryos.
A new study performed an “umbrella review” on the use of supplements for improving female infertility, finding that while studies show improvements in pregnancy outcomes, the quality of the data is low and “insufficient to recommend nutrient supplementation.”
A 2024 study combined the results of 14 studies analyzing how hysteroscopy impacts IVF success, finding improvements in live birth rate, pregnancy rate and no change in miscarriage rate.
A 2025 study found that live birth rates increased with endometrial thickness up to about 9 mm, after which they plateaued.
A new study reviewed how fibroids can compromise the endometrium and prevent embryo implantation, identifying key issues such as disrupted blood flow and vascular changes, abnormal endometrial peristalsis, inflammatory responses, and changes in the microbiome.
