Researchers in a 2021 study performed a clinical trial and found that low and moderate level mosaic embryos have comparable pregnancy outcomes to euploid embryo transfers.
Embryoman
Researchers in a 2020 study found that sperm from males in couples with recurrent pregnancy loss were more likely to be aneuploid, potentially leading to the diagnosis.
Researchers in a 2021 study investigated “self-correction” in a stem cell-based model for mosaic embryos and found that aneuploid cells in a mosaic are more likely to change into trophectoderm cells or die, while euploid cells accumulate in the ICM.
Researchers in a 2020 study performed a clinical trial and transferred aneuploid embryos, finding that no whole chromosome aneuploids led to a live birth, while segmental aneuploids did.
Researchers in a 2021 study compared outcomes from 1,000 mosaic embryo transfers, consisting of high and low level, as well as whole chromosome or segmental mosaics.
This post takes a closer look at what “poor-quality” embryos really mean in IVF. At the cleavage stage, they often have fewer cells or high fragmentation, while at the blastocyst stage, a grade C means the inner cell mass and trophectoderm contain fewer, loosely packed cells. These embryos tend to have lower success rates than good-quality ones, but studies show they can have similar perinatal outcomes.
Researchers in a 2019 study compared euploid transfer outcomes for day 5, 6 or 7 euploids, finding that day 7 embryos have good potential.
Researchers in a 2019 study compared IVF outcomes from men with low or high sperm DNA fragmentation, finding that high SDF patients had poorer quality blastocysts and a higher chance of miscarriage.
This post discusses the use of supplements to improve egg quality for IVF success, exploring the supporting evidence for a range of supplements like N-acetyl-cysteine, Melatonin, L-arginine, Myo-inositol, CoQ10, L-carnitine, DHEA, folic acid/folate, and vitamins E, C, D, and B.
This post covers mosaic embryos, including their definition, frequency after PGT-A, mosaic embryo levels (low level, high level), mosaic embryo types (whole chromosome, segmental), current guidelines for transfer, potential for self-correction, and success rates.
